The postdoctoral fellow will work on HIV 1 env vaccine development and modulation of B cell affinity maturation.He or she will explore humoral and cell mediated autoimmune responses induced by vaccination and underlying mechanisms of breaking immune tolerance. Mouse model immunization studies, immune sera analyses, FACS for immune cells analyses, B cell repertoire analysi

Technical proficiency, scientific creativity, collaboration with others and independent thought. Design, conduct, and troubleshoot hypothesis testing experiments. Design, conduct, and validate high throughput, hypothesis generating screens. Mentoring of research technicians and undergraduate students. Maintain detailed and understandable lab notebooks and records. Interpr

The ideal candidate will additionally possess excellent experimental planning and execution skills, good communications skills, an open and creative mind, and a desire to collaborate with others. The candidate will lead independent research projects, report progress and track deliverables, work to develop innovative approaches to advance the field of tumor immunology and

The Fischer Lab at Dana Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology and chemistry with various 'Omics' techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via the ubiquitin proteasome system that are often as

N/A Qualifications PhD degree in chemical biology or a related discipline Strong background in synthetic organic chemistry, to enable delivery of chemical probes Familiarity with chemical biology techniques used to assess interactions between proteins and small molecules. Experience in biochemical/biophysical assay development Experience in chemoproteomics is desirable Ex

Design and implement studies to evaluate determinants of pancreatic cancer risk and outcomes. Collaborate with other laboratory members with expertise in epidemiology, biostatistics, pathology, molecular biology, and functional genomics. Conduct analyses using statistical software, such as SAS, R, and others. Participate in group meetings and work collaboratively on large

Performing cell and molecular biology research including but not limited to 2D and 3D cell culture, genetic manipulation through shRNA/CRISPR, protein/RNA/DNA analyses including Western blotting, RNA seq, IP MS, and ChIP seq. Lentiviral transduction techniques for ORF overexpression experiments or RNAi and CRISPR Cas9 knockdown/knockout experiments. Performing a variety o

The position will involve the study of myeloid neoplasms and will lead to significant experience in a wide range of techniques, including cell culture, genome engineering, protein biochemistry, flow cytometry, genetic screening, RNAseq, proteomics, and human tissue biomarker analysis. Developing independence will be fostered and opportunities for inter laboratory, multidi

Laboratory Operations Institute, maintain, and improve standard procedures for laboratory efficiencies, including monitoring laboratory expenditure. Responsible for overseeing efficient inventory maintenance and ordering. This includes flow antibodies, restriction enzymes, proteins, plasmids, and DNA to name a few. Responsible, directly or indirectly, for care, repair and

Oversees needs of a laboratory composed initially by 4 members, with growth expectations to up to 16 members. At Dana Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equ

Clinical Trials Operations Clinical Research Managers (CRM) are responsible for the oversight of their disease group's clinical trial portfolio and all related regulatory, compliance and performance metrics requirements. The CRM will oversee the processing of protocols through DFCI Institutional Review Board (and other institutions' IRBs) when appropriate. The CRM will co

Orients and assists in training new staff. Qualifications Bachelor's Degree and 1 3 years of equivalent experience required. Experience working in a medical or scientific research setting or comparable technology orientated business environment preferred. COMPETENCIES Demonstrates understanding of CRF completion, including timely and accurate transcription of study data S

Oversight of the clinical trials start up process from receipt of protocols through the Scientific Review Committee and IRB submissions, and site activation activities. Responsible for data reporting and management, collection of source documents, use and development of case report forms, adverse events reporting, filing and archiving of study records, and resolution of d

Responsible for data reporting and management, collection of source documents, use and development of case report forms, adverse events reporting, filing and archiving of study records, and resolution of data queries. Assist in preparation and or completion of regulatory related reports and IRB submissions. Maintain and organize study regulatory binders, enter all require

Coordinate data reporting and management, collection of source documents, use and development of case report forms, adverse events reporting, filing and archiving of study records, and resolution of data queries. Assist with the preparation and/or completion of regulatory related reports and IRB submissions. Maintain and organize study regulatory binders, enter all requir